The non-susceptibility rate to 3rd/4th generation cephalosporins steadily increased over the last 10 years.
Equally to E. coli, Klebsiella pneumoniae, belong to the family of Enterobacteriaceae and are potentially causing urinary tract infections. In addition, they are known to cause pneumonia, particularly in the hospital setting. The non-susceptibility rate in K. pneumoniae to 3rd/4th generation cephalosporins increased from 1.3% in 2004 to 10.4% in 2018, which was comparable to the increase in E. coli. However, rates of 3rd/4th generation cephalosporin resistant K. pneumoniae have remained constant during the last four years.
Patients with a K. pneumoniae infection in the hospital setting are generally isolated, due to an increased risk of transmission.
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95% CI: 95% confidence interval
For this analysis invasive isolates (blood and cerebrospinal fluid) tested against the corresponding antibiotic (category) were considered only. If multiple antibiotics within the same antibiotic category were tested, the most resistant result was selected. In case of multiple isolates, the first isolate per patient, microorganism and calendar year was included only. Results are reported as delivered by laboratories. Statistics may be influenced by the changing number of laboratories participating. Data are provided for surveillance purposes and are not intended to be used for therapeutic decisions solely.