NRP 49 "Antibiotic resistance"

The National Research Programme "Antibiotic resistance" (NRP 49) intended to focus on establishing scientific strategies and new methods applicable to a prospective system of resistance monitoring and on the analysis of the current situation concerning resistance in Switzerland, in all relevant areas (human and animal populations, agriculture, foodstuffs and the environment). The mobility of resistant bacteria or resistance genes and the resulting risk for future therapies have been evaluated. Molecular studies on the emergence of antibiotic resistance provided new knowledge for the development of new antibiotics and new methods of in vitro detection. Furthermore, social, legal, ethical and economical consequences of the development of antibiotic resistance and a possible modification of rulings on the use of antibiotics have been estimated. NRP 49 was conducted over the period 2001–2006. Its pioneering achievements led to the creation of the Swiss Centre for Antibiotic Resistance (Anresis).

Final Report of NRP 49 (PDF, 5.7 MB)


NRP 72 « Antimicrobial Resistance »

On 24 June 2015, the Federal Council approved the new National Research Programme "Antimicrobial Resistance" (NRP 72) and mandated the Swiss National Science Foundation (SNSF) to conduct the NRP. NRP 72 is now focusing more closely on applied research. One reason for this shift in emphasis is the major advances achieved in recent years in the field of gene sequencing and the biochemical analysis of cellular processes. These advances are the foundations of new approaches to research and solutions.

The objective of NRP 72 is to contribute to reducing antimicrobial resistance as well as decreasing its negative impact on the therapy of infectious diseases. Since antimicrobial-resistant bacteria are present in human and animal hosts as well as in the environment, NRP is addressing the issue with a one-health approach. The overall funding for NFP 72 amounts to CHF 20 million for 5 years of research (2017-2021).